Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853169 | 1.00 | RXFP1 (0.36) | RXFP1SMN1; SMN2ALDH1A1MAPK1SYK | |
| SCHEMBL23218979 | 0.81 | MAP4K3 (0.32) | SYK | |
| SCHEMBL29852777 | 0.80 | TBXAS1 (0.43) | SMN1; SMN2ALDH1A1MAPK1SYKPOLB | |
| SCHEMBL23218919 | 0.80 | TBXAS1 (0.43) | SMN1; SMN2ALDH1A1MAPK1SYKPOLB | |
| SCHEMBL29852957 | 0.80 | PIM1 (0.52) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL23218355 | 0.80 | PIM1 (0.52) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL29591204 | 0.78 | JMJD6 (0.42) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL23218802 | 0.78 | JMJD6 (0.42) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL23218491 | 0.77 | MMP9 (0.37) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 | |
| SCHEMBL29852830 | 0.77 | MMP9 (0.37) | RXFP1SMN1; SMN2ALDH1A1MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |