Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29591445 | 1.00 | ALOX15 (0.36) | ALOX15KDM4EHTR1AHTR1DHTR2C | |
| SCHEMBL23218458 | 0.83 | CFD (0.37) | ALOX15KDM4EHTR1AHTR1DHTR2C | |
| SCHEMBL29592306 | 0.83 | CFD (0.37) | ALOX15KDM4EHTR1AHTR1DHTR2C | |
| SCHEMBL29592710 | 0.82 | CFD (0.49) | CD274CFDPPARD | |
| SCHEMBL23218539 | 0.82 | CFD (0.49) | CD274CFDPPARD | |
| SCHEMBL23218238 | 0.81 | PPARD (0.38) | ALOX15KDM4EHTR1AHTR1DHTR2C | |
| SCHEMBL29592722 | 0.81 | PPARD (0.38) | ALOX15KDM4EHTR1AHTR1DHTR2C | |
| SCHEMBL29592081 | 0.79 | CFD (0.43) | CD274CFDFFAR1PPARD | |
| SCHEMBL23218864 | 0.79 | CFD (0.43) | CD274CFDFFAR1PPARD | |
| SCHEMBL23218388 | 0.77 | CD274 (0.43) | KDM4ECD274CFDMAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |