Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 2/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852603 | 1.00 | TBXAS1 (0.39) | TBXAS1CFDDUSP3PTPN5PTPN11 | |
| SCHEMBL28736126 | 0.89 | DUSP3 (0.45) | CFDDUSP3PTPN5PTPN11CTDSP1 | |
| SCHEMBL29591758 | 0.88 | TBXAS1 (0.38) | TBXAS1CFDDUSP3PTPN5PTPN11 | |
| SCHEMBL23219185 | 0.88 | TBXAS1 (0.38) | TBXAS1CFDDUSP3PTPN5PTPN11 | |
| SCHEMBL23219252 | 0.85 | TBXAS1 (0.39) | TBXAS1CFDDUSP3PTPN5PTPN11 | |
| SCHEMBL29592062 | 0.85 | TBXAS1 (0.39) | TBXAS1CFDDUSP3PTPN5PTPN11 | |
| SCHEMBL28736356 | 0.84 | RAD52 (0.35) | DUSP3PTPN5PTPN11CTDSP1APEX1 | |
| SCHEMBL23219184 | 0.83 | CFD (0.49) | CFDF11TPSB2 | |
| SCHEMBL29852669 | 0.83 | CFD (0.49) | CFDF11TPSB2 | |
| SCHEMBL28736330 | 0.80 | TBXAS1 (0.39) | TBXAS1CFDDUSP3PTPN5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |