Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852973 | 0.87 | CFD (0.51) | CFDCD274PLAUPLGF11 | |
| SCHEMBL23218519 | 0.87 | CFD (0.51) | CFDCD274PLAUPLGF11 | |
| SCHEMBL29853135 | 0.85 | CFD (0.45) | CFDCD274PDCD1PLAUPLG | |
| SCHEMBL23218836 | 0.85 | CFD (0.45) | CFDCD274PDCD1PLAUPLG | |
| SCHEMBL29852753 | 0.78 | CFD (0.56) | CFDPLAUPLGF11KLKB1 | |
| SCHEMBL23218338 | 0.78 | CFD (0.56) | CFDPLAUPLGF11KLKB1 | |
| SCHEMBL29852754 | 0.76 | CFD (0.48) | CFDCD274PDCD1PLAUPLG | |
| SCHEMBL23218099 | 0.76 | CFD (0.48) | CFDCD274PDCD1PLAUPLG | |
| SCHEMBL23218900 | 0.74 | CFD (0.66) | CFDPLAUPLGF11KLKB1 | |
| SCHEMBL29591366 | 0.74 | CFD (0.66) | CFDPLAUPLGF11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |