Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 16/20 | 0.47 |
| ▸ | TPSB2 | P20231 | 9/20 | 0.47 |
| ▸ | F11 | P03951 | 9/20 | 0.47 |
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852922 | 1.00 | CFD (0.47) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL23219087 | 0.92 | CFD (0.48) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL29852733 | 0.92 | CFD (0.48) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL29592594 | 0.86 | CFD (0.50) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL23219083 | 0.86 | CFD (0.50) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL23219211 | 0.86 | CFD (0.62) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL29593174 | 0.86 | CFD (0.62) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL23218585 | 0.84 | CFD (0.53) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL29591910 | 0.84 | CFD (0.53) | CFDTPSB2F11PLAUPLG | |
| SCHEMBL23219242 | 0.82 | CFD (0.47) | CFDTPSB2F11PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |