Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 7/20 | 0.48 |
| ▸ | F11 | P03951 | 4/20 | 0.37 |
| ▸ | TPSB2 | P20231 | 4/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852733 | 1.00 | CFD (0.48) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL23219198 | 0.92 | CFD (0.47) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL29852922 | 0.92 | CFD (0.47) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL29852822 | 0.90 | CFD (0.39) | CFDHTR1ADRD2TBXAS1SLC1A5 | |
| SCHEMBL23219250 | 0.90 | CFD (0.39) | CFDHTR1ADRD2TBXAS1SLC1A5 | |
| SCHEMBL23218809 | 0.87 | CFD (0.52) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL29852792 | 0.87 | CFD (0.52) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL23219243 | 0.86 | CFD (0.62) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL29853182 | 0.86 | CFD (0.62) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL23218719 | 0.85 | CFD (0.41) | CFDNOS3NOS1NOS2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |