Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SELPLG | Q14242 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20940100 | 0.86 | GABRA1 (0.39) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL22526089 | 0.85 | TSHR (0.47) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL9626890 | 0.83 | GABRA1 (0.55) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL357875 | 0.81 | TSHR (0.61) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL16952335 | 0.80 | GABRA1 (0.42) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL22336043 | 0.78 | CYP4F2 (0.47) | TSHRSLC6A2 | |
| SCHEMBL22306685 | 0.77 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL18533077 | 0.77 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3RORC | |
| SCHEMBL21259631 | 0.77 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3RORC | |
| SCHEMBL21776121 | 0.76 | TSHR (0.48) | TSHRGABRA1GABRG2GABRB3RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | INCYTE CORPORATION (US) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | PIK3R5, PIK3CD, PIK3CA | TSHR 1103/4885GABRA1 1626/4885GABRG2 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.