Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746668 | 0.88 | RIPK1 (0.43) | RIPK1ESR1ESR2TRPA1TAAR1 | |
| SCHEMBL18927458 | 0.86 | RIPK1 (0.36) | RIPK1ESR1ESR2TAAR1 | |
| SCHEMBL20178582 | 0.84 | SLC2A1 (0.39) | — | |
| SCHEMBL782013 | 0.82 | ALDH1A1 (0.44) | — | |
| SCHEMBL21503575 | 0.82 | ALDH1A1 (0.44) | — | |
| SCHEMBL18286641 | 0.82 | ALDH1A1 (0.44) | — | |
| SCHEMBL19122074 | 0.81 | ALDH1A1 (0.44) | TRPA1 | |
| SCHEMBL10446001 | 0.79 | CA12 (0.47) | RIPK1ESR1ESR2 | |
| SCHEMBL18685712 | 0.77 | TSHR (0.48) | RIPK1ESR1ESR2TAAR1 | |
| SCHEMBL2407454 | 0.77 | GRIA4 (0.42) | RIPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | INCYTE CORPORATION (US) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | PIK3R5, PIK3CD, PIK3CA | RIPK1 710/4885ESR1 3323/4885ESR2 2010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.