Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15139546 | 0.93 | GAA (0.47) | ALDH1A1GAATHRBATML3MBTL1 | |
| SCHEMBL771850 | 0.89 | GAA (0.53) | ALDH1A1GAAPOLBHPGDEPHX1 | |
| Hydrochloric Acid SCHEMBL12494569 | 0.87 | GAA (0.51) | ALDH1A1GAAPOLBHPGDEPHX1 | |
| SCHEMBL16512381 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| SCHEMBL3316653 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| SCHEMBL14827284 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| SCHEMBL12481132 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| SCHEMBL9987783 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| SCHEMBL304391 | 0.82 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 | |
| Methyl Alcohol SCHEMBL11559156 | 0.80 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1POLBHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975100-B2 | Fused bicyclic inhibitors of menin-MLL interaction | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975100-B2 | Fused bicyclic inhibitors of menin-MLL interaction | MLLT1, BMI1, MEN1 | ALDH1A1 3997/4885GAA 4461/4885THRB 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.