Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597126 | 0.81 | CYP1A2 (0.54) | CYP1A2MAPK1ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL23809638 | 0.79 | ASIC3 (0.59) | MAPK1KDM4EABL1MAPTBCR | |
| SCHEMBL1445810 | 0.78 | MIF (0.57) | MAPK1FYNKDM4EABL1MAPT | |
| SCHEMBL23221307 | 0.77 | ABL1 (0.58) | CYP1A2MAPK1HSD17B10TP53ALOX15 | |
| SCHEMBL3664142 | 0.77 | FYN (0.57) | MAPK1FYNABL1KDM1ALIMK1 | |
| SCHEMBL5562447 | 0.76 | CYP1A2 (0.48) | CYP1A2MAPK1ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL4108901 | 0.75 | ABL1 (0.58) | CYP1A2MAPK1ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL23221380 | 0.74 | CYP1A2 (0.62) | CYP1A2MAPK1ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL842300 | 0.73 | PARP1 (0.61) | FYNABL1BCRKDM1AKMO | |
| SCHEMBL1445168 | 0.73 | FYN (0.52) | MAPK1FYNKDM4EABL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523291-B1 | CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-04-14 | — | — | EP | disclosed |