SCHEMBL2322146

SCHEMBL2322146

NCc1cc(-c2ccnc(Nc3cccc(OC(F)(F)C(F)F)c3)n2)ccn1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 5/20 0.74
BCR P11274 5/20 0.74
PRKCA P17252 4/20 0.74
CSNK2A1 P68400 2/20 0.66
SRC P12931 3/20 0.60
EGFR P00533 2/20 0.60
PRKACA P17612 2/20 0.60
PRKACG P22612 2/20 0.60
PRKACB P22694 2/20 0.60
PRKCD Q05655 2/20 0.60
PDGFRB P09619 1/20 0.57
PDGFRA P16234 1/20 0.57
PIK3CG P48736 4/20 0.49
PIK3CA P42336 3/20 0.49
PIK3CB P42338 3/20 0.48
CCNB2 O95067 1/20 0.47
CCNE2 O96020 1/20 0.47
CDK1 P06493 1/20 0.47
FGFR1 P11362 1/20 0.47
CDK4 P11802 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2323502 0.92 ABL1 (0.65) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837915 0.87 ABL1 (0.79) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL3390712 0.86 ABL1 (0.66) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837795 0.86 ABL1 (0.80) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL1269 0.86 ABL1 (1.00) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837830 0.85 ABL1 (0.70) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837759 0.85 ABL1 (0.76) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837798 0.85 CSNK2A1 (0.81) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837807 0.85 PRKCA (0.79) ABL1BCRPRKCACSNK2A1SRC
SCHEMBL8837875 0.85 ABL1 (0.78) ABL1BCRPRKCACSNK2A1SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2011-12-01 US claimed
US-5612340-A ANTITUMOR AGENTS CIBA-GEIGY CORPORATION (US) 1997-03-18 US claimed
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2011-12-01 US disclosed
EP-2356102-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS Bayer CropScience AG (DE) 2011-08-17 EP disclosed
WO-2010055114-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE SA (FR) 2010-05-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS PRXL2A, AZI2, PIR ABL1 801/4885BCR 3173/4885PRKCA 4168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.