Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.48 |
| ▸ | CLK1 | P49759 | 5/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | STK4 | Q13043 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013879 | 0.82 | LRRK2 (0.65) | LRRK2STK4STK3NTRK1 | |
| SCHEMBL4350812 | 0.81 | KDR (0.57) | JAK3LRRK2DYRK1ASTK3PIM1 | |
| SCHEMBL16783676 | 0.76 | BACE1 (0.40) | LRRK2DYRK1ANTRK1 | |
| SCHEMBL30046544 | 0.76 | KDM4E (0.49) | PIM1PIM3PIM2 | |
| SCHEMBL20162994 | 0.73 | LRRK2 (0.40) | JAK3LRRK2DYRK1ASTK4STK3 | |
| SCHEMBL22037742 | 0.73 | LRRK2 (0.45) | JAK3LRRK2STK4STK3RET | |
| SCHEMBL28057753 | 0.72 | LRRK2 (0.62) | JAK3LRRK2DYRK1ASTK3NTRK1 | |
| SCHEMBL14163023 | 0.71 | CHEK1 (0.62) | LRRK2STK4STK3 | |
| SCHEMBL28057752 | 0.71 | RET (0.48) | JAK3LRRK2DYRK1ASTK4STK3 | |
| SCHEMBL30538088 | 0.70 | LRRK2 (0.47) | JAK3LRRK2RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318565-B1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | PFIZER (US) | 2021-04-14 | — | — | EP | disclosed |