Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ABL2 | P42684 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257351 | 0.84 | MAPT (0.56) | KDRKMT2ABRAFTNNI3KLCK | |
| SCHEMBL7013879 | 0.83 | LRRK2 (0.65) | KDRSRCABL1EGFRABL2 | |
| SCHEMBL1896766 | 0.83 | STK3 (0.58) | KDRPPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL410257 | 0.83 | NUDT14 (0.55) | KDRKMT2ASRCEGFRTEK | |
| SCHEMBL29552165 | 0.83 | NUDT14 (0.55) | KDRKMT2ASRCEGFRTEK | |
| SCHEMBL24710755 | 0.83 | LRRK2 (0.51) | KDRLCKKITLIMK1JAK2 | |
| SCHEMBL2073031 | 0.82 | LCK (0.54) | KDRSRCTEKLCKLIMK1 | |
| Bromide SCHEMBL6865619 | 0.82 | NUDT14 (0.54) | KDRKMT2ASRCEGFRTEK | |
| SCHEMBL23221981 | 0.81 | JAK3 (0.48) | JAK3NTRK1PIM1FLT3STK3 | |
| SCHEMBL3787081 | 0.80 | SRC (0.50) | KDRSRCABL1BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |
| EP-0888353-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO 2,3-D]PYRIDINES AND THEIR USE | Novartis AG (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034895-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO[2,3-D]PYRIDINES AND THEIR USE | NOVARTIS AG (CH) | 1997-09-25 | — | — | WO | disclosed |