Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24710755 | 0.85 | LRRK2 (0.51) | RETNTRK1LRRK2MAPK1DYRK1A | |
| SCHEMBL7021288 | 0.85 | LRRK2 (0.63) | RETNTRK1LRRK2MAPK1BRAF | |
| SCHEMBL1896766 | 0.82 | STK3 (0.58) | RETNTRK1LRRK2MAPK1DYRK1A | |
| SCHEMBL4352960 | 0.82 | LRRK2 (0.58) | RETNTRK1LRRK2DYRK1APRKD3 | |
| SCHEMBL23917432 | 0.82 | LRRK2 (0.50) | RETNTRK1LRRK2MAPK1DYRK1A | |
| SCHEMBL8107167 | 0.82 | FLT3 (0.46) | RETNTRK1LRRK2MAPK1DYRK1A | |
| SCHEMBL3787081 | 0.82 | SRC (0.50) | RETNTRK1LRRK2BRAFTNNI3K | |
| SCHEMBL8107173 | 0.81 | FLT3 (0.46) | RETNTRK1LRRK2MAPK1DYRK1A | |
| SCHEMBL28057753 | 0.81 | LRRK2 (0.62) | NTRK1LRRK2MAPK1DYRK1APRKD3 | |
| SCHEMBL4350812 | 0.78 | KDR (0.57) | NTRK1LRRK2MAPK1BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |