⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168756 | 0.79 | — | — | |
| SCHEMBL270679 | 0.75 | — | — | |
| SCHEMBL51848 | 0.68 | — | — | |
| SCHEMBL1715624 | 0.68 | — | — | |
| SCHEMBL51804 | 0.68 | — | — | |
| SCHEMBL410636 | 0.67 | — | — | |
| SCHEMBL506048 | 0.67 | — | — | |
| SCHEMBL8445953 | 0.67 | ALDH1A1 (0.41) | — | |
| SCHEMBL11723553 | 0.67 | — | — | |
| SCHEMBL127346 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | claimed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | claimed |
| CN-86100954-A | The preparation method of therapeutical agent and application | — | 1986-09-03 | — | — | CN | claimed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | claimed |
| CN-103442712-B | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SAI NUOFEI (FR) | 2016-01-20 | — | — | CN | disclosed |
| CN-103459374-B | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SAI NUOFEI (FR) | 2015-11-25 | — | — | CN | disclosed |
| CN-102884052-B | O-substituted 3-heteroaroylamino-propionic acid derivatives and their pharmaceutical use | SAI NUOFEI (FR) | 2015-10-21 | — | — | CN | disclosed |
| US-9120783-B2 | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-09-01 | — | — | US | disclosed |
| US-9029559-B2 | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-05-12 | — | — | US | disclosed |
| US-8962671-B2 | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-02-24 | — | — | US | disclosed |
| EP-2826772-A1 | Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives | SANOFI (FR) | 2015-01-21 | — | — | EP | disclosed |
| EP-2668167-B1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2014-12-17 | — | — | EP | disclosed |
| WO-2012101199-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-08-02 | — | — | WO | disclosed |
| WO-2011092187-A1 | OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2011-08-04 | — | — | WO | disclosed |
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| CN-1012733-B | Process for the preparation of therapeutic agents | BOOTS CO PLC (GB) | 1991-06-05 | — | — | CN | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| CN-86100954-A | The preparation method of therapeutical agent and application | — | 1986-09-03 | — | — | CN | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |