Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2318752 | 0.95 | CYP3A4 (0.49) | CYP3A4GRM2GRM3 | |
| SCHEMBL2318475 | 0.90 | CYP3A4 (0.55) | CYP3A4GRM2GRM3 | |
| SCHEMBL2316903 | 0.89 | CYP3A4 (0.53) | CYP3A4GRM2GRM3 | |
| SCHEMBL2320081 | 0.88 | CYP3A4 (0.42) | CYP3A4GRM2GRM3 | |
| SCHEMBL2316819 | 0.86 | CYP3A4 (0.51) | CYP3A4GRM2GRM3 | |
| SCHEMBL4554423 | 0.85 | CYP3A4 (0.50) | CYP3A4GRM2GRM3 | |
| SCHEMBL2319166 | 0.85 | CYP3A4 (0.53) | CYP3A4GRM2GRM3 | |
| SCHEMBL2318644 | 0.84 | CYP3A4 (0.54) | CYP3A4GRM2GRM3 | |
| SCHEMBL5563704 | 0.83 | CYP3A4 (0.70) | CYP3A4GRM2GRM3 | |
| SCHEMBL2319078 | 0.82 | CYP3A4 (0.51) | CYP3A4GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137167-B1 | DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| EP-2137167-A1 | DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-12-30 | — | — | EP | disclosed |
| US-7511033-B2 | Dihydro-benzo[B][1,4]diazepin-2-one sulfonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2008128889-A1 | DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-30 | — | — | WO | disclosed |
| US-20080261957-A1 | DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261957-A1 | DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES | SULT2A1, SULT1A1, CNR1 | CYP3A4 251/4885GRM2 69/4885GRM3 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.