Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.56 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323148 | 1.00 | CRHR1 (0.56) | CRHR1DRD2CRHR2DRD3SMYD3 | |
| Hydrochloric Acid SCHEMBL2364861 | 0.94 | CRHR1 (0.52) | CRHR1DRD2CRHR2DRD3SMYD3 | |
| Hydrochloric Acid SCHEMBL2364863 | 0.94 | CRHR1 (0.52) | CRHR1DRD2CRHR2DRD3SMYD3 | |
| Hydrochloric Acid SCHEMBL2364862 | 0.81 | CRHR1 (0.49) | CRHR1DRD2CRHR2SMYD3 | |
| SCHEMBL27877443 | 0.78 | CRHR1 (0.49) | CRHR1CRHR2 | |
| SCHEMBL27877441 | 0.76 | CRHR1 (0.46) | CRHR1CRHR2SMYD3L3MBTL1 | |
| SCHEMBL27877442 | 0.76 | CRHR1 (0.46) | CRHR1CRHR2SMYD3L3MBTL1 | |
| SCHEMBL17685467 | 0.76 | CRHR1 (0.51) | CRHR1DRD2CRHR2 | |
| SCHEMBL17685468 | 0.76 | CRHR1 (0.51) | CRHR1DRD2CRHR2 | |
| SCHEMBL1849402 | 0.76 | CRHR1 (0.54) | CRHR1DRD2DRD3KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531490-B1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2014-10-15 | — | — | EP | disclosed |
| US-8835444-B2 | Cyclohexyl amide derivatives as CRF receptor antagonists | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | disclosed |
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | NOVARTIS AG (CH) | 2012-12-13 | — | — | US | disclosed |
| EP-2531490-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011095450-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316185-A1 | Cyclohexyl Amide Derivatives as CRF Receptor Antagonists | CRHR2, CRHR1, CRH | CRHR1 2/4885DRD2 329/4885CRHR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.