Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324523 | 1.00 | ADRA1A (0.45) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2323971 | 1.00 | ADRA1A (0.45) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2326748 | 0.88 | CHRNB2 (0.39) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2321313 | 0.87 | TRPV1 (0.40) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8995630 | 0.86 | CHRNB2 (0.39) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8995649 | 0.85 | PDK2 (0.40) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14837801 | 0.84 | ADRA1A (0.37) | ADRA1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2322176 | 0.81 | CHRNB2 (0.42) | ADRA1AHTR1ASLC6A2SLC6A4CHRNB2 | |
| SCHEMBL457401 | 0.79 | HTR2C (0.56) | HTR1ASLC6A2SLC6A4SLC6A3CHRNB2 | |
| SCHEMBL29589456 | 0.79 | HTR2C (0.56) | HTR1ASLC6A2SLC6A4SLC6A3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203077-B | (pyrrolidin-2-yl) phenyl derivatives for the treatment of pain | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | claimed |
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | claimed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | claimed |
| EP-2356105-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. Organon (NL) | 2011-08-17 | — | — | EP | claimed |
| WO-2010052198-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. ORGANON (NL) | 2010-05-14 | — | — | WO | claimed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | claimed |
| CN-102203077-B | (pyrrolidin-2-yl) phenyl derivatives for the treatment of pain | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | disclosed |
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| EP-2356105-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. Organon (NL) | 2011-08-17 | — | — | EP | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| EP-1045915-A2 | REGULATION OF BIOLOGICAL EVENTS USING MULTIMERIC CHIMERIC PROTEINS | ARIAD GENE THERAPEUTICS, INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999036553-A2 | REGULATION OF BIOLOGICAL EVENTS USING MULTIMERIC CHIMERIC PROTEINS | ARIAD GENE THERAPEUTICS, INC. (US) | 1999-07-22 | — | — | WO | disclosed |
| EP-0833894-A1 | RAPAMCYCIN-BASED REGULATION OF BIOLOGICAL EVENTS | ARIAD GENE THERAPEUTICS, INC. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996041865-A1 | RAPAMCYCIN-BASED REGULATION OF BIOLOGICAL EVENTS | ARIAD GENE THERAPEUTICS, INC. (US) | 1996-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | CNR1, CNR2, TRPV1 | ADRA1A 520/4885HTR1A 1773/4885SLC6A2 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.