Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29246740 | 0.92 | SMN1; SMN2 (0.43) | L3MBTL1TDP1SMN1; SMN2GLAGAA | |
| SCHEMBL29771757 | 0.92 | SMN1; SMN2 (0.43) | L3MBTL1TDP1SMN1; SMN2GLAGAA | |
| SCHEMBL11317160 | 0.87 | LMNA (0.47) | L3MBTL1TDP1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL30584236 | 0.87 | THRB (0.45) | TDP1SMN1; SMN2GLAGAAALDH1A1 | |
| SCHEMBL29246742 | 0.87 | THRB (0.45) | TDP1SMN1; SMN2GLAGAAALDH1A1 | |
| SCHEMBL24498698 | 0.85 | THRB (0.50) | SMN1; SMN2GLAALDH1A1HPGDTHRA | |
| SCHEMBL27340448 | 0.84 | LMNA (0.53) | L3MBTL1TDP1GAAALDH1A1HPGD | |
| SCHEMBL29771742 | 0.83 | CSNK2A1 (0.45) | TDP1SMN1; SMN2ALDH1A1DPP4HPGD | |
| SCHEMBL29246744 | 0.83 | CSNK2A1 (0.45) | TDP1SMN1; SMN2ALDH1A1DPP4HPGD | |
| SCHEMBL28421317 | 0.82 | LMNA (0.46) | L3MBTL1TDP1SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021071802-A1 | ARYL HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2021-04-15 | — | — | WO | disclosed |