Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 7/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.45 |
| ▸ | UNG | P13051 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzaldehyde SCHEMBL11615486 | 0.84 | ALDH1A1 (0.52) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Benzaldehyde SCHEMBL11615481 | 0.84 | ALDH1A1 (0.52) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Leucine SCHEMBL10670394 | 0.83 | SLC7A5 (0.60) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| D-Glutamate SCHEMBL28109572 | 0.83 | GRIK1 (0.60) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Glutamic Acid SCHEMBL28109571 | 0.83 | GRIK1 (0.60) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Benzaldehyde SCHEMBL28125082 | 0.82 | PTGS1 (0.57) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Benzaldehyde SCHEMBL8698780 | 0.82 | PTGS1 (0.57) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Biphenyl SCHEMBL7779541 | 0.81 | SLC1A3 (0.62) | GRIK1GRIK2ALPIPKMPTGS1 | |
| Benzaldehyde SCHEMBL10916118 | 0.81 | ALDH1A1 (0.48) | GRIK1GRIK2ALDH1A1CYP2A6ALPI | |
| Phenylalanine SCHEMBL2225062 | 0.81 | SLC7A5 (0.76) | ALDH1A1CYP2A6ALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223619-A1 | ENGINEERED BIOCATALYSTS FOR THE SYNTHESIS OF GAMMA-HYDROXY AMINO ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2025-07-10 | — | — | US | disclosed |
| US-12281341-B2 | Engineered biocatalysts for the synthesis of gamma-hydroxy amino acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2025-04-22 | — | — | US | disclosed |
| US-20240150802-A1 | ENGINEERED BIOCATALYSTS FOR THE SYNTHESIS OF GAMMA-HYDROXY AMINO ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2024-05-09 | — | — | US | disclosed |
| US-11591626-B2 | Engineered biocatalysts for the synthesis of gamma-hydroxy amino acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210115480-A1 | ENGINEERED BIOCATALYSTS FOR THE SYNTHESIS OF GAMMA-HYDROXY AMINO ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2021-04-22 | — | — | US | disclosed |