Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 5/20 | 0.62 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.62 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.62 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.53 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL28292719 | 0.86 | ALPI (0.52) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Aspartic Acid SCHEMBL7709510 | 0.86 | SLC7A5 (0.53) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Aspartic Acid SCHEMBL7709515 | 0.86 | SLC7A5 (0.53) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Aspartic Acid SCHEMBL2772548 | 0.84 | TSHR (0.54) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Aspartic Acid SCHEMBL7781975 | 0.84 | GRIK1 (0.61) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Aspartic Acid SCHEMBL2772547 | 0.84 | TSHR (0.54) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Phenylalanine SCHEMBL398714 | 0.82 | SLC7A5 (0.81) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Dl-Phenylalanine SCHEMBL1897792 | 0.82 | SLC7A5 (0.81) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Phenylalanine SCHEMBL7248684 | 0.82 | SLC7A5 (0.81) | SLC1A3SLC1A2SLC1A1ALPIPKM | |
| Benzamide SCHEMBL28175462 | 0.82 | TSHR (0.59) | SLC1A3SLC1A2SLC1A1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135398-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | Monsanto Technology LLC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6218563-B1 | Cyanophosphonamides and method for preparation | MONSANTO COMPANY | 2001-04-17 | — | — | US | disclosed |
| WO-2000032611-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | MONSANTO TECHNOLOGY LLC (US) | 2000-06-08 | — | — | WO | disclosed |