Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 16/20 | 0.61 |
| ▸ | THRB | P10828 | 16/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24449950 | 0.79 | THRA (0.65) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24449324 | 0.76 | THRA (0.62) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL23260588 | 0.76 | THRA (0.64) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24821078 | 0.76 | THRA (0.65) | THRATHRBCYP2C8CYP2C9BCAT1 | |
| SCHEMBL29163707 | 0.73 | THRA (0.59) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24449322 | 0.72 | THRA (0.63) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL29163702 | 0.72 | THRA (0.59) | THRATHRBCYP2C8CYP2C9BCAT1 | |
| SCHEMBL29134033 | 0.72 | THRA (0.60) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL25074237 | 0.71 | THRA (0.65) | THRATHRBCYP2C8CYP2C9 | |
| SCHEMBL24820488 | 0.71 | THRA (0.58) | THRATHRBCYP2C8CYP2C9BCAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358899-B2 | Thyroid hormone receptor agonists and uses thereof | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2025-07-15 | — | — | US | disclosed |
| EP-4574208-A2 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2025-06-25 | — | — | EP | disclosed |
| EP-3807267-B1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | XIZANG HAISCO PHARMACEUTICAL CO LTD (CN) | 2025-03-19 | — | — | EP | disclosed |
| US-20240360106-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | XIZANG HAISCO PHARMACEUTICAL CO LTD (CN) | 2024-10-31 | — | — | US | disclosed |
| US-11964964-B2 | Thyroid hormone receptor agonists and uses thereof | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2024-04-23 | — | — | US | disclosed |
| US-20210115022-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
| US-20210115022-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964964-B2 | Thyroid hormone receptor agonists and uses thereof | TSHR, THRA, TRHR | THRA 2/4885THRB 4/4885CYP2C8 1430/4885 |
| US-20210115022-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | TSHR, THRA, TRHR | THRA 2/4885THRB 4/4885CYP2C8 1430/4885 |
| US-20240360106-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF | TSHR, THRA, TRHR | THRA 2/4885THRB 4/4885CYP2C8 1430/4885 |
| US-12358899-B2 | Thyroid hormone receptor agonists and uses thereof | TSHR, THRA, TRHR | THRA 2/4885THRB 4/4885CYP2C8 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.