SCHEMBL2324599

SCHEMBL2324599

CCN(C(=O)O)C1(CC(C)C)CCN(c2cnc3cc(Cl)ccc3n2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 3/20 0.50
PDE10A Q9Y233 2/20 0.40
PTPN11 Q06124 1/20 0.38
HCRTR1 O43613 4/20 0.38
HCRTR2 O43614 4/20 0.38
SORD Q00796 1/20 0.38
PPARD Q03181 2/20 0.37
PPARG P37231 1/20 0.37
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CNR1 P21554 4/20 0.36
KCNH2 Q12809 2/20 0.36
DGAT1 O75907 1/20 0.36
CYP2C9 P11712 1/20 0.35
LTC4S Q16873 1/20 0.35
HTR3A P46098 1/20 0.34
HCAR2 Q8TDS4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2331854 0.90 HRH4 (0.54) HRH4PDE10APTPN11HCRTR1HCRTR2
SCHEMBL2324589 0.78 HRH4 (0.48) HRH4PDE10APTPN11HCRTR1HCRTR2
SCHEMBL2331484 0.74 HRH4 (0.58) HRH4PDE10AKDM4ENPC1MAPT
SCHEMBL2360815 0.72 HRH4 (0.53) HRH4PDE10APTPN11HCRTR1HCRTR2
SCHEMBL345648 0.71 HRH4 (0.38) HRH4PDE10APTPN11HCRTR1HCRTR2
SCHEMBL2331847 0.71 HRH4 (0.52) HRH4PDE10APTPN11HCRTR1HCRTR2
SCHEMBL2332308 0.69 HRH4 (0.57) HRH4PDE10AKDM4ENPC1MAPT
SCHEMBL2331480 0.69 HRH4 (0.54) HRH4PDE10AKCNH2DGAT1
SCHEMBL607451 0.68 HRH4 (1.00) HRH4KDM4ENPC1MAPTRAB9A
SCHEMBL344754 0.67 HRH4 (0.40) HRH4PDE10APTPN11HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2356108-B1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-10-15 EP disclosed
EP-2356108-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-08-17 EP disclosed
WO-2010055267-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-05-20 WO disclosed