Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Risedronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 11/20 | 0.81 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.81 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.81 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Risedronic Acid SCHEMBL2324063 | 1.00 | FDPS (0.81) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL18378 | 0.90 | FDPS (1.00) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL29362587 | 0.90 | FDPS (1.00) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL2115054 | 0.88 | FDPS (0.97) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL4989214 | 0.88 | FDPS (0.97) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL3170751 | 0.88 | FDPS (0.97) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL3771017 | 0.88 | FDPS (0.97) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL2115050 | 0.88 | FDPS (0.97) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL22720092 | 0.87 | FDPS (0.94) | FDPSBTN3A1PDE3ANAPRTCYP1A2 | |
| Risedronic Acid SCHEMBL22720090 | 0.87 | FDPS (0.94) | FDPSBTN3A1PDE3ANAPRTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362071-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Grünenthal GmbH (DE) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017049294-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| EP-2531200-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Thar Pharmaceuticals, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011097269-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2011-08-11 | — | — | WO | disclosed |