Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Risedronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 12/20 | 0.97 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.97 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Risedronic Acid SCHEMBL4989214 | 1.00 | FDPS (0.97) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL22720092 | 0.98 | FDPS (0.94) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL18378 | 0.98 | FDPS (1.00) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL29362587 | 0.98 | FDPS (1.00) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL2115050 | 0.97 | FDPS (0.97) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL3771017 | 0.97 | FDPS (0.97) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL2115054 | 0.97 | FDPS (0.97) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL22720090 | 0.95 | FDPS (0.94) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL4643040 | 0.90 | FDPS (0.83) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Risedronic Acid SCHEMBL5970387 | 0.90 | FDPS (0.78) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476451-B1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMA (IL) | 2010-03-17 | — | — | EP | claimed |
| WO-2007042048-A2 | METHOD FOR PREPARING CRYSTALLINE SODIUM RISEDRONATE | SANDOZ A/S (DK) | 2007-04-19 | — | — | WO | claimed |
| EP-1775302-A1 | Method for preparing crystalline sodium risedronate | Sandoz A/S (DK) | 2007-04-18 | — | — | EP | claimed |
| US-7038083-B2 | Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-05-02 | — | — | US | claimed |
| CN-1665825-A | Use of certain diluents for making bisphosphonic acids | TEVA PHARMA (IL) | 2005-09-07 | — | — | CN | claimed |
| EP-1476451-A1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-17 | — | — | EP | claimed |
| US-20040043967-A1 | Novel process for making bisphosphonic acids using diluents other than halogenated hydrocarbons | TEVA PHARMACEUTICALS USA, INC. | 2004-03-04 | — | — | US | claimed |
| WO-2003097655-A1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-11-27 | — | — | WO | claimed |
| US-20100317859-A1 | Process for the Preparation of Risedronate Sodium | ACTAVIS GROUP PTC EHF (IS) | 2010-12-16 | — | — | US | disclosed |
| US-20100121066-A1 | Novel Process For Preparing Risedronic Acid | ALKEM LABORATORIES LIMITED (IN) | 2010-05-13 | — | — | US | disclosed |
| EP-1476451-B1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMA (IL) | 2010-03-17 | — | — | EP | disclosed |
| US-20090209763-A1 | Novel Process For Making Bisphosphonic Acids Using Diluents Other Than Halogenated Hydrocarbons | LIDOR-HADAS RAMI | 2009-08-20 | — | — | US | disclosed |
| WO-2009050731-A2 | NOVEL PROCESS FOR PREPARING RISEDRONIC ACID | ALKEM LABORATORIES LTD (IN) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009034580-A1 | IMPROVED PROCESS FOR THE PREPARATION OF RISEDRONATE SODIUM HEMIPENTAHYDRATE | FLEMING LABORATORIES LIMITED (IN) | 2009-03-19 | — | — | WO | disclosed |
| US-20060128960-A1 | Novel process for making bisphosphonic acids using diluents other than halogenated hydrocarbons | LIDOR-HADAS RAMI | 2006-06-15 | — | — | US | disclosed |
| US-7038083-B2 | Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-05-02 | — | — | US | disclosed |
| CN-1665825-A | Use of certain diluents for making bisphosphonic acids | TEVA PHARMA (IL) | 2005-09-07 | — | — | CN | disclosed |
| EP-1476451-A1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-17 | — | — | EP | disclosed |
| US-20040043967-A1 | Novel process for making bisphosphonic acids using diluents other than halogenated hydrocarbons | TEVA PHARMACEUTICALS USA, INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003097655-A1 | USE OF CERTAIN DILUENTS FOR MAKING BISPHOSPHONIC ACIDS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317859-A1 | Process for the Preparation of Risedronate Sodium | PPIP5K2, PDE8B, HMGCR | FDPS 23/4885BTN3A1 4441/4885PDE3A 379/4885 |
| US-20100121066-A1 | Novel Process For Preparing Risedronic Acid | PPIP5K2, PEX3, PHYKPL | FDPS 666/4885BTN3A1 1162/4885PDE3A 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.