Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578263 | 0.82 | PRSS1 (0.45) | PRSS1TMPRSS2 | |
| SCHEMBL23068921 | 0.81 | KDM4E (0.46) | KDM4EMAPTHTTPRSS1 | |
| SCHEMBL18104847 | 0.80 | PRSS1 (0.41) | PRSS1TMPRSS2 | |
| SCHEMBL548439 | 0.78 | PRSS1 (0.60) | PRSS1L3MBTL1GAATMPRSS2 | |
| SCHEMBL549185 | 0.78 | TMPRSS2 (0.60) | PRSS1L3MBTL1TMPRSS2 | |
| SCHEMBL498377 | 0.77 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| Pentamidine Dao SCHEMBL548448 | 0.77 | PRMT1 (0.61) | PRSS1L3MBTL1GAATMPRSS2 | |
| SCHEMBL2323023 | 0.77 | EPHX2 (0.46) | NPC1RAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL20946216 | 0.76 | MAPK14 (0.47) | KDM4EMAPTMEN1KMT2ALMNA | |
| SCHEMBL409427 | 0.75 | NR1I2 (0.53) | SMN1; SMN2MAPTALDH1A1PRSS1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356112-A1 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054764-A1 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |