Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | GPR3 | P46089 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18380932 | 0.92 | SCN5A (0.56) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL4800915 | 0.90 | MAPT (0.53) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL1119471 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL2037249 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL2259946 | 0.88 | CA12 (0.50) | ALDH1A1MAPTCYP2C9CYP17A1CYP2C19 | |
| SCHEMBL1710060 | 0.88 | NPC1 (0.47) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL7026279 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL9682 | 0.88 | MAPT (0.63) | ALDH1A1MAPTGPR3SCN5ASMN1; SMN2 | |
| SCHEMBL9458453 | 0.88 | APP (0.50) | ALDH1A1MAPTGPR3SCN5ACYP2C9 | |
| SCHEMBL3271257 | 0.88 | APP (0.47) | ALDH1A1MAPTCYP2C9CYP17A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063292-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYTOLUENES. | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-03-11 | — | — | US | claimed |
| US-6586598-B2 | Reacting 2,5-bis(2,2,2- trifluoroethoxy)- alpha , alpha -dibromo- alpha -chloro acetophenone with 2-(aminomethyl)pyridine to form 2,5-bis(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)-benzamide, and reducing | GENEVA PHARMACEUTICALS, INC. | 2003-07-01 | — | — | US | claimed |
| US-20020188130-A1 | Alpha, alpha-dibromo-alpha-chloro-acetophenones as synthons | RAY ANUP K (US) | 2002-12-12 | — | — | US | claimed |
| WO-2002066413-A1 | FLECAINIDE SYNTHESIS | NARCHEM CORPORATION (US) | 2002-08-29 | — | — | WO | claimed |
| US-4684733-A | Process for the preparation of intermediates of derivatives of pyrrolidine and piperidine | RIKER LABORATORIES, INC. (US) | 1987-08-04 | — | — | US | claimed |
| US-4675448-A | Chlorination process | ETHYL CORPORATION (US) | 1987-06-23 | — | — | US | claimed |
| US-4650873-A | Process for the preparation of a derivative of piperidine | RIKER LABORATORIES (US) | 1987-03-17 | — | — | US | claimed |
| US-4617396-A | Process for the preparation of derivatives of piperidine | RIKER LABORATORIES, INC. (US) | 1986-10-14 | — | — | US | claimed |
| JP-1125341-A | — | — | None | — | — | JP | disclosed |
| JP-1104044-A | — | — | None | — | — | JP | disclosed |
| JP-1125342-A | — | — | None | — | — | JP | disclosed |
| JP-1125339-A | — | — | None | — | — | JP | disclosed |
| JP-1125344-A | — | — | None | — | — | JP | disclosed |
| JP-1125343-A | — | — | None | — | — | JP | disclosed |
| US-4650873-A | Process for the preparation of a derivative of piperidine | RIKER LABORATORIES (US) | 1987-03-17 | — | — | US | disclosed |
| US-4642384-A | Process for the preparation of derivatives of pyrrolidine and piperidine | RIKER LABORATORIES, INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4617396-A | Process for the preparation of derivatives of piperidine | RIKER LABORATORIES, INC. (US) | 1986-10-14 | — | — | US | disclosed |
| US-4491584-A | ANTIARRHYTHMIA AGENTS | RIKER LABORATORIES (US) | 1985-01-01 | — | — | US | disclosed |
| US-4154941-A | ANTIARRHYTHMIC AGENTS | RIKER LABORATORIES, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4071524-A | Derivatives of urea | RIKER LABORATORIES, INC. (US) | 1978-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188130-A1 | Alpha, alpha-dibromo-alpha-chloro-acetophenones as synthons | CYP2D6, CYP2B6, CYP2A6 | ALDH1A1 251/4885MAPT 3968/4885GPR3 3175/4885 |
| US-20100063292-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYTOLUENES. | CYP2C9, CYP3A4, CYP3A5 | ALDH1A1 1392/4885MAPT 3131/4885GPR3 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.