Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13243615 | 0.80 | DRD2 (0.42) | DRD3DRD2TP53MAPTLMNA | |
| SCHEMBL7163458 | 0.78 | DRD2 (0.50) | DRD3DRD2TP53TSHRMAPT | |
| SCHEMBL25997014 | 0.77 | KCNH2 (0.41) | HTR2CHTR2ADRD3DRD2TP53 | |
| SCHEMBL18914238 | 0.77 | HTR2C (0.49) | HTR2CHTR2ADRD3DRD2HTR1D | |
| SCHEMBL23956117 | 0.76 | HTR2C (0.60) | HTR2CHTR2ADRD3TP53NPC1 | |
| SCHEMBL16064395 | 0.76 | HTR2C (0.44) | HTR2CHTR2AHTR1DROS1ALK | |
| SCHEMBL3658413 | 0.76 | HTR2C (0.44) | HTR2CHTR2AHTR1D | |
| SCHEMBL2001744 | 0.75 | DRD2 (0.47) | DRD3DRD2TSHRMAPTLMNA | |
| SCHEMBL16423236 | 0.75 | MAPT (0.39) | DRD3DRD2TP53TSHRMAPT | |
| SCHEMBL22971668 | 0.74 | HTR2C (0.43) | HTR2CHTR2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076902-A1 | INHIBITING HUMAN INTEGRIN α 4 β 7 | MORPHIC THERAPEUTIC, INC. (US) | 2021-04-22 | — | — | WO | disclosed |