Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15702056 | 0.93 | SSTR3 (0.50) | SPHK1SPHK2 | |
| SCHEMBL13166473 | 0.92 | SPHK1 (0.50) | SPHK1SPHK2 | |
| SCHEMBL14140557 | 0.87 | LTA4H (0.52) | BACE1PLG | |
| SCHEMBL19719375 | 0.87 | LTA4H (0.52) | BACE1PLG | |
| SCHEMBL26025959 | 0.86 | OPRK1 (0.49) | KMT2AMEN1BACE1 | |
| SCHEMBL16450329 | 0.84 | SMN1; SMN2 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL23286133 | 0.84 | SMN1; SMN2 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28356671 | 0.84 | BACE1 (0.60) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL23477267 | 0.84 | BACE1 (0.60) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL29651398 | 0.81 | GNPAT (0.56) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030244-B1 | POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO | ARROWHEAD PHARMACEUTICALS INC (US) | 2021-04-21 | — | — | EP | disclosed |