SCHEMBL23257589

SCHEMBL23257589

CC(C)(F)C(=O)N(CC(=O)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ncccc21)Cc1ccccc1CN1CCC1

nearest known ligand 0.90

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADM2 Q7Z4H4 20/20 0.90
CALCB P10092 19/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23257433 0.94 ADM2 (1.00) ADM2CALCB
SCHEMBL29814027 0.94 ADM2 (1.00) ADM2CALCB
SCHEMBL23257100 0.93 ADM2 (0.97) ADM2CALCB
SCHEMBL29813988 0.90 ADM2 (0.85) ADM2CALCB
SCHEMBL29814104 0.90 ADM2 (0.80) ADM2CALCB
SCHEMBL23257395 0.90 ADM2 (0.80) ADM2CALCB
SCHEMBL23257374 0.90 ADM2 (0.85) ADM2CALCB
SCHEMBL23257443 0.90 ADM2 (0.89) ADM2CALCB
SCHEMBL23257606 0.90 ADM2 (0.83) ADM2CALCB
SCHEMBL29813694 0.90 ADM2 (0.83) ADM2CALCB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3628045-B1 COMPOUNDS UNIV SHEFFIELD (GB) 2024-07-03 EP disclosed
US-20210113534-A1 COMPOUNDS THE UNIVERSITY OF SHEFFIELD (GB) 2021-04-22 US disclosed
CN-110891951-A Compound (I) 谢菲尔德大学 2020-03-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210113534-A1 COMPOUNDS MRGPRX2, MC2R, ADM2 ADM2 3/4885CALCB 133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.