Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200943 | 0.92 | MET (0.53) | METKDR | |
| SCHEMBL3829110 | 0.84 | MET (0.47) | METKDR | |
| SCHEMBL3855044 | 0.84 | MET (0.55) | METKDR | |
| SCHEMBL19689580 | 0.83 | MET (0.55) | METKDR | |
| SCHEMBL407662 | 0.83 | MET (0.57) | METAXL | |
| SCHEMBL15519428 | 0.82 | MET (0.53) | METKDRAXL | |
| SCHEMBL3830213 | 0.82 | MET (0.47) | METKDR | |
| SCHEMBL3858219 | 0.81 | MET (0.55) | METKDR | |
| SCHEMBL407663 | 0.81 | MET (0.46) | METKDR | |
| SCHEMBL371857 | 0.80 | MET (0.61) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |