Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | MST1R | Q04912 | 2/20 | 0.51 |
| ▸ | HGF | P14210 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326114 | 0.92 | MET (0.52) | METKDR | |
| SCHEMBL3855044 | 0.91 | MET (0.55) | METKDRMST1RHGF | |
| SCHEMBL3829110 | 0.91 | MET (0.47) | METKDRMST1R | |
| SCHEMBL19689580 | 0.91 | MET (0.55) | METKDRMST1RHGF | |
| SCHEMBL15519428 | 0.90 | MET (0.53) | METKDR | |
| SCHEMBL407662 | 0.89 | MET (0.57) | MET | |
| SCHEMBL407663 | 0.88 | MET (0.46) | METKDRMST1R | |
| SCHEMBL3830213 | 0.88 | MET (0.47) | METKDRMST1RHGF | |
| SCHEMBL3858219 | 0.86 | MET (0.55) | METKDR | |
| SCHEMBL29693560 | 0.85 | MET (0.52) | METKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |