Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.75 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561258 | 0.86 | SIRT6 (1.00) | SIRT6GPR27ALDH1A1 | |
| SCHEMBL23260610 | 0.85 | SIRT6 (0.84) | SIRT6GPR27IDH1 | |
| SCHEMBL23261498 | 0.85 | SIRT6 (0.84) | SIRT6GPR27IDH1 | |
| SCHEMBL28883674 | 0.84 | SIRT6 (0.83) | SIRT6GPR27IDH1 | |
| SCHEMBL28355358 | 0.84 | SIRT6 (0.83) | SIRT6GPR27IDH1 | |
| SCHEMBL28355884 | 0.84 | SIRT6 (0.83) | SIRT6GPR27IDH1 | |
| SCHEMBL23246158 | 0.84 | SIRT6 (0.83) | SIRT6GPR27IDH1 | |
| SCHEMBL23246163 | 0.84 | SIRT6 (0.83) | SIRT6GPR27IDH1 | |
| SCHEMBL23260705 | 0.84 | SIRT6 (1.00) | SIRT6GPR27ALDH1A1GAAIDH1 | |
| SCHEMBL29546685 | 0.84 | SIRT6 (1.00) | SIRT6GPR27ALDH1A1GAAIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |