Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.83 |
| ▸ | GPR27 | Q9NS67 | 3/20 | 0.41 |
| ▸ | ACLY | P53396 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 5/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | RRM1 | P23921 | 1/20 | 0.37 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23246158 | 1.00 | SIRT6 (0.83) | SIRT6GPR27ACLYPOLBIDH1 | |
| SCHEMBL23260610 | 0.99 | SIRT6 (0.84) | SIRT6GPR27ACLYPOLBIDH1 | |
| SCHEMBL28883674 | 0.98 | SIRT6 (0.83) | SIRT6GPR27ACLYPOLBIDH1 | |
| SCHEMBL23246163 | 0.98 | SIRT6 (0.83) | SIRT6GPR27ACLYPOLBIDH1 | |
| SCHEMBL29561258 | 0.91 | SIRT6 (1.00) | SIRT6GPR27ACLYFABP4FABP5 | |
| SCHEMBL28355158 | 0.91 | SIRT6 (0.70) | SIRT6GPR27ACLYFABP4FABP5 | |
| SCHEMBL23261498 | 0.90 | SIRT6 (0.84) | SIRT6GPR27ACLYIDH1FABP4 | |
| SCHEMBL28359044 | 0.90 | SIRT6 (0.69) | SIRT6GPR27ACLYFABP4FABP5 | |
| SCHEMBL23260705 | 0.89 | SIRT6 (1.00) | SIRT6GPR27ACLYIDH1FABP4 | |
| SCHEMBL29546685 | 0.89 | SIRT6 (1.00) | SIRT6GPR27ACLYIDH1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |