Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.49 |
| ▸ | AR | P10275 | 5/20 | 0.49 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31595469 | 0.91 | CRBN (0.50) | CRBNARBTKCDK9PLK4 | |
| SCHEMBL31595777 | 0.86 | CRBN (0.53) | CRBNARBTKPLK4ALK | |
| SCHEMBL31595268 | 0.81 | CRBN (0.49) | CRBNARBTKCDK9PLK4 | |
| SCHEMBL31595385 | 0.77 | CRBN (0.46) | CRBNBTKHPGDSPTK2DDB1 | |
| SCHEMBL23267690 | 0.77 | CRBN (0.46) | CRBNBTKHPGDSPTK2DDB1 | |
| SCHEMBL24299348 | 0.77 | CRBN (0.66) | CRBNARBTKCDK9PLK4 | |
| SCHEMBL29986989 | 0.77 | CRBN (0.66) | CRBNARBTKCDK9PLK4 | |
| SCHEMBL23268079 | 0.77 | CRBN (0.69) | CRBNARBTKCDK9IRAK1 | |
| SCHEMBL24819369 | 0.77 | CRBN (0.69) | CRBNARBTKCDK9PLK4 | |
| SCHEMBL23134695 | 0.76 | CRBN (0.58) | CRBNARBTKCDK9PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021077010-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | ARVINAS OPERATIONS, INC. (US) | 2021-04-22 | — | — | WO | disclosed |