Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.66 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.61 |
| ▸ | AR | P10275 | 4/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986989 | 1.00 | CRBN (0.66) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL30984751 | 0.93 | CRBN (0.60) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL30984978 | 0.93 | CRBN (0.62) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL25384391 | 0.91 | CRBN (0.66) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL29260077 | 0.91 | CRBN (0.69) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL30984742 | 0.90 | CRBN (0.61) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL25172415 | 0.90 | CRBN (0.80) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL30400867 | 0.90 | CRBN (0.80) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL23117898 | 0.90 | CRBN (0.58) | CRBNDDB1ARCDK9BTK | |
| SCHEMBL23134695 | 0.90 | CRBN (0.58) | CRBNDDB1ARCDK9BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274418-A1 | PROTEOLYSIS-TARGETING CHIMERIC COMPOUND | 南京明德新药研发有限公司 | 2023-01-05 | — | — | WO | disclosed |
| WO-2022048605-A1 | HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATIONS | 南昌奥瑞药业有限公司 | 2022-03-10 | — | — | WO | disclosed |