Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 12/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327045 | 0.91 | FPR2 (0.65) | FPR2HCRTR2HCRTR1GSK3B | |
| SCHEMBL2327727 | 0.89 | HCRTR2 (0.58) | FPR2HCRTR2HCRTR1 | |
| SCHEMBL2324608 | 0.89 | FPR2 (0.69) | FPR2HCRTR2HCRTR1CACNA1H | |
| SCHEMBL2330879 | 0.88 | HCRTR2 (0.60) | FPR2HCRTR2HCRTR1 | |
| SCHEMBL1166044 | 0.88 | HCRTR2 (0.56) | FPR2HCRTR2HCRTR1CACNA1HHDAC1 | |
| SCHEMBL2328926 | 0.87 | HCRTR2 (0.72) | FPR2HCRTR2HCRTR1 | |
| SCHEMBL2328979 | 0.86 | FPR2 (0.64) | FPR2HCRTR2HCRTR1 | |
| SCHEMBL2323231 | 0.86 | FPR2 (0.68) | FPR2HCRTR2HCRTR1GSK3B | |
| SCHEMBL2328204 | 0.86 | HCRTR2 (0.58) | FPR2HCRTR2HCRTR1 | |
| SCHEMBL2327838 | 0.86 | HCRTR2 (0.58) | FPR2HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |