Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | NAMPT | P43490 | 10/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138026 | 0.87 | GPR119 (0.63) | GPR119MCHR1 | |
| SCHEMBL19356221 | 0.84 | GPR119 (0.50) | GPR119NAMPTLIPE | |
| SCHEMBL17559447 | 0.81 | HRH3 (0.50) | GPR119NAMPTLIPE | |
| SCHEMBL19473350 | 0.81 | NAMPT (0.48) | GPR119NAMPTLIPE | |
| SCHEMBL20069064 | 0.80 | TDO2 (0.47) | NAMPTLIPE | |
| SCHEMBL26587921 | 0.80 | ACACB (0.40) | GPR119LIPE | |
| SCHEMBL20147462 | 0.78 | HRH3 (0.54) | — | |
| SCHEMBL20069055 | 0.77 | RET (0.39) | GPR119MCHR1LIPE | |
| SCHEMBL10136290 | 0.77 | ACACB (0.44) | MCHR1 | |
| SCHEMBL17232472 | 0.77 | ACACB (0.46) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |