Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.62 |
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21011946 | 1.00 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL21012042 | 1.00 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL538174 | 0.84 | HTR7 (0.76) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL274149 | 0.81 | HTR7 (1.00) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL8325204 | 0.81 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL23875876 | 0.81 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL23876089 | 0.81 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL7488979 | 0.81 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL25215212 | 0.80 | HTR7 (0.57) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL6786360 | 0.79 | HTR7 (0.78) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355884-B1 | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS | OLEMA PHARMACEUTICALS INC (US) | 2021-04-28 | — | — | EP | disclosed |