Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21012042 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL8325204 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL21011946 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL23875876 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL23876089 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL23280535 | 0.80 | HTR7 (0.67) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL538174 | 0.79 | HTR7 (0.76) | HTR7CYP3A4CYP2D6CYP2C19PRMT5 | |
| SCHEMBL24443878 | 0.78 | ABCG2 (0.52) | KMT2AMAPTMEN1ESR1 | |
| SCHEMBL21012023 | 0.77 | ESR1 (0.58) | KMT2AMAPTMAPK1ESR1 | |
| SCHEMBL23793705 | 0.77 | ESR1 (0.58) | KMT2AMAPTMAPK1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4629971-A1 | DOSAGE FORMS OF AN ESTROGEN RECEPTOR ANTAGONIST | Olema Pharmaceuticals, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124182-A1 | DOSAGE FORMS OF AN ESTROGEN RECEPTOR ANTAGONIST | OLEMA PHARMACEUTICALS, INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| US-20240131013-A1 | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS | OLEMA PHARMACEUTICALS INC (US) | 2024-04-25 | — | — | US | disclosed |
| US-11672785-B2 | Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs | OLEMA PHARMACEUTICALS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| WO-2023091550-A1 | METHODS OF TREATING ESTROGEN RECEPTOR-ASSOCIATED DISEASES | OLEMA PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11672785-B2 | Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs | ESR1, CYP19A1, HSD17B11 | HTR7 119/4885CYP3A4 46/4885CYP2D6 44/4885 |
| US-20240131013-A1 | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS | ESR1, CYP19A1, HSD17B11 | HTR7 119/4885CYP3A4 46/4885CYP2D6 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.