Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19261817 | 0.86 | TLR4 (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13039144 | 0.84 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3286457 | 0.83 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL20822144 | 0.82 | BRD4 (0.41) | ALDH1A1GAACHRM2CHRM4CHRM5 | |
| SCHEMBL10654584 | 0.81 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2782732 | 0.81 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10296047 | 0.81 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5871351 | 0.80 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2127522 | 0.80 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11568317 | 0.79 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170823-B1 | 6,7-DIHYDRO-2H-PYRAZOLO[4,3-C]PYRIDIN-3(5H)-ONE DERIVATIVES AND THEIR USE FOR TREATING A DISEASE ASSOCIATED WITH AMPK KINASE ACTIVITY | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-04-28 | — | — | EP | disclosed |