Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23280774 | 0.86 | MAPT (0.49) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL12633310 | 0.83 | ALDH1A1 (0.48) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1622272 | 0.82 | GAA (0.50) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL542220 | 0.81 | MEN1 (0.47) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1134463 | 0.80 | ALDH1A1 (0.53) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL12134814 | 0.78 | ALDH1A1 (0.45) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL19841984 | 0.78 | ALDH1A1 (0.46) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL19841968 | 0.78 | ALDH1A1 (0.46) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL12606807 | 0.77 | TLR4 (0.52) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL321283 | 0.77 | TLR4 (0.52) | TLR4ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738649-B2 | Tetrahydro-pyrimidoazepines as modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-08-22 | — | — | US | disclosed |