Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL10653813 | 0.97 | MAPT (0.43) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL10654314 | 0.93 | MAPT (0.43) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL31454859 | 0.91 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL533925 | 0.91 | LMNA (0.45) | MAPTALDH1A1LMNAGAAKDM4E | |
| Ethylene SCHEMBL10844325 | 0.90 | MAPT (0.41) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL5871351 | 0.89 | MAPT (0.44) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL2127522 | 0.89 | MAPT (0.44) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL29450286 | 0.89 | MAPT (0.46) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL183637 | 0.89 | MAPT (0.46) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL9310424 | 0.88 | MAPT (0.38) | MAPTALDH1A1LMNAGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126654-B1 | TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF | H. LUNDBECK A/S (DK) | 1988-05-04 | — | — | EP | disclosed |
| US-4608378-A | Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems | H. LUNDBECK A/S (DK) | 1986-08-26 | — | — | US | disclosed |
| EP-0126654-A1 | Tetrahydroisoxazolo(4,5-c)pyridine derivatives and preparation thereof | H. LUNDBECK A/S (DK) | 1984-11-28 | — | — | EP | disclosed |