SCHEMBL23283552

SCHEMBL23283552

Cc1cc(-n2cc(Cl)c3c(N)ncnc32)ccc1F

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 17/20 0.55
EGFR P00533 3/20 0.45
SRC P12931 3/20 0.45
CDK1 P06493 2/20 0.45
ABL1 P00519 2/20 0.45
KDR P35968 2/20 0.45
ABL2 P42684 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23283550 0.74 METTL3 (0.52) METTL3EGFRSRCCDK1ABL1
SCHEMBL23283390 0.74 METTL3 (0.54) METTL3EGFRSRCCDK1ABL1
SCHEMBL23283551 0.74 METTL3 (0.57) METTL3EGFRSRCCDK1ABL1
SCHEMBL24635165 0.72 METTL3 (1.00) METTL3
SCHEMBL23283517 0.69 METTL3 (0.62) METTL3
SCHEMBL13192053 0.67 ADORA2A (0.46) EGFRSRCABL1KDR
SCHEMBL15087029 0.65 SRC (0.58) EGFRSRCABL1KDR
SCHEMBL2800044 0.64 SRC (0.60) EGFRSRCCDK1ABL1KDR
SCHEMBL7833854 0.64 SRC (0.86) EGFRSRCCDK1ABL1KDR
SCHEMBL7843429 0.64 SRC (0.70) EGFRSRCCDK1ABL1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021081211-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2021-04-29 WO disclosed