Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23285224 | 0.86 | OPRM1 (0.45) | CYP2D6ALDH1A1TSHRCYP3A4MEN1 | |
| SCHEMBL23285195 | 0.77 | CYP2D6 (0.48) | CYP2D6ALDH1A1TSHRCYP3A4GAA | |
| SCHEMBL23285220 | 0.74 | CYP2D6 (0.42) | CYP2D6ALDH1A1TSHRCYP3A4GAA | |
| SCHEMBL2284694 | 0.70 | CYP2D6 (0.59) | CYP2D6ALDH1A1TSHRCYP3A4GAA | |
| SCHEMBL23089517 | 0.69 | CYP2D6 (0.46) | CYP2D6ALDH1A1TSHRCYP3A4GAA | |
| SCHEMBL23285145 | 0.69 | OPRL1 (0.39) | CYP2D6TSHRCYP3A4SIGMAR1 | |
| SCHEMBL23274837 | 0.69 | CYP3A4 (0.49) | CYP2D6ALDH1A1TSHRCYP3A4MEN1 | |
| SCHEMBL2344239 | 0.68 | SIGMAR1 (0.56) | CYP2D6ALDH1A1TSHRCYP3A4GAA | |
| SCHEMBL17714545 | 0.67 | OPRM1 (0.51) | ALDH1A1TSHRCYP3A4MEN1KMT2A | |
| SCHEMBL6263041 | 0.66 | SIGMAR1 (0.54) | CYP2D6ALDH1A1TSHRCYP3A4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081272-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2021-04-29 | — | — | WO | disclosed |