Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474709 | 0.86 | KMT2A (0.70) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL31022695 | 0.83 | MEN1 (0.62) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL758991 | 0.83 | MEN1 (0.62) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL2615685 | 0.82 | CYP1A2 (0.53) | ALDH1A1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL1901172 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL24548087 | 0.81 | TDP1 (0.62) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| Acetic Acid SCHEMBL6444184 | 0.81 | MEN1 (0.60) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL895009 | 0.81 | PARP1 (0.63) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL7041993 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL29761319 | 0.81 | PARP1 (0.63) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023202583-A1 | FXR REGULATOR AND USE THEREOF | 北京大学 | 2023-10-26 | — | — | WO | disclosed |
| CN-116903559-A | FXR modulators and uses thereof | 北京大学 | 2023-10-20 | — | — | CN | disclosed |
| US-9340522-B2 | Pyrazolone-derivatives and their use as PDE-4 inhibitors | TAKEDA GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| EP-2356103-B1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | TAKEDA GMBH (DE) | 2015-08-26 | — | — | EP | disclosed |
| CN-102369194-B | Pyrazolone derivatives and their use as PD4 inhibitors | NYCOMED GMBH | 2014-08-27 | — | — | CN | disclosed |
| US-20140073672-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | TAKEDA GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8609848-B2 | Pyrazolone-derivatives and their use as PDE-4 inhibitors | TAKEDA GMBH (DE) | 2013-12-17 | — | — | US | disclosed |
| CN-102369194-A | Novel pyrazolone derivatives and their use as PD4 inhibitors | NYCOMED GMBH | 2012-03-07 | — | — | CN | disclosed |
| US-20110218201-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | NYCOMED GMBH (DE) | 2011-09-08 | — | — | US | disclosed |
| EP-2356103-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | Nycomed GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055083-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-20 | — | — | WO | disclosed |
| EP-0718277-B1 | Method for producing 5-substituted-2-acylaminophenols, and 5-alkyl-2-acylaminophenol compound and N-acyl-N-(4-alkyl-phenyl)hydroxylamine compound | FUJI PHOTO FILM CO LTD (JP) | 1999-07-21 | — | — | EP | disclosed |
| EP-0718277-A1 | Method for producing 5-substituted-2-acylaminophenols, and 5-alkyl-2-acylaminophenol compound and N-acyl-N-(4-alkyl-phenyl)hydroxylamine compound | FUJI PHOTO FILM CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |
| EP-0352222-B1 | Fibre-reactive formazane dyes, process for their preparation and their use | CIBA GEIGY AG (CH) | 1994-05-25 | — | — | EP | disclosed |
| US-5114430-A | Colorfast dyes that react with fibers to form red, orange or red color | CIBA-GEIGY CORPORATION (US) | 1992-05-19 | — | — | US | disclosed |
| US-4994562-A | Colorfast; for dyeing wool, silk | CIBA-GEIGY CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0405101-A1 | Reactive dyes | BAYER AG (DE) | 1991-01-02 | — | — | EP | disclosed |
| EP-0399292-A1 | Reactive dyes | BAYER AG (DE) | 1990-11-28 | — | — | EP | disclosed |
| EP-0352222-A2 | Fibre-reactive formazane dyes, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1990-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218201-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | PDE4A, PDE3B, PDE3A | ALDH1A1 344/4885HSD17B10 199/4885CYP1A2 237/4885 |
| US-20140073672-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | PDE4A, PDE3B, PDE3A | ALDH1A1 344/4885HSD17B10 199/4885CYP1A2 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.