Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 19/20 | 0.62 |
| ▸ | THRB | P10828 | 19/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23287581 | 0.94 | THRA (0.63) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287579 | 0.92 | THRA (0.62) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287555 | 0.92 | THRA (0.64) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287578 | 0.91 | THRA (0.60) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287522 | 0.90 | THRB (0.62) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287601 | 0.90 | THRB (0.62) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287571 | 0.89 | THRA (0.62) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287519 | 0.89 | THRA (0.56) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287554 | 0.89 | THRA (0.58) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23287558 | 0.89 | THRA (0.61) | THRATHRBCYP2C9CYP2C8UGT1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4050008-A1 | PYRIDAZINONE OR PYRIDAZINE COMPOUND AND DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2022-08-31 | — | — | EP | disclosed |
| WO-2021078274-A1 | PYRIDAZINONE OR PYRIDAZINE COMPOUND AND DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF | 苏州泽璟生物制药股份有限公司 | 2021-04-29 | — | — | WO | disclosed |