Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27240085 | 0.84 | KDR (0.41) | RXFP1GRM5KDM4EKDRLCK | |
| SCHEMBL27240259 | 0.79 | GRM5 (0.38) | RXFP1GRM5TP53KDM4EKMT2A | |
| SCHEMBL4310554 | 0.78 | VCP (0.45) | RXFP1KMT2APTPN11RAB9ANPC1 | |
| SCHEMBL7043137 | 0.76 | PTPN11 (0.59) | KDM4EALDH1A1KMT2APTPN11RAB9A | |
| SCHEMBL27240040 | 0.76 | GRM5 (0.41) | RXFP1GRM5KDM4EALDH1A1KMT2A | |
| SCHEMBL23287985 | 0.75 | BTK (0.40) | RXFP1PTPN11KDRLCKCA12 | |
| SCHEMBL19233276 | 0.74 | KDM4E (0.46) | RXFP1KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL1706042 | 0.73 | PTGES (0.43) | RXFP1PTPN11 | |
| SCHEMBL23287990 | 0.73 | MEN1 (0.39) | GRM5KMT2ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27240225 | 0.73 | SYK (0.37) | RXFP1KDRLCKTEKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021080013-A1 | INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-04-29 | — | — | WO | disclosed |