Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326027 | 0.93 | LMNA (0.48) | OPRM1OGFRL1LMNATP53OPRL1 | |
| SCHEMBL698242 | 0.90 | OPRM1 (0.46) | OPRM1OGFRL1OPRL1TRPV1CDK4 | |
| SCHEMBL700114 | 0.89 | OPRM1 (0.44) | OPRM1OGFRL1LMNATP53OPRL1 | |
| SCHEMBL699917 | 0.89 | LMNA (0.45) | OPRM1OGFRL1LMNATP53OPRL1 | |
| SCHEMBL698513 | 0.89 | OPRM1 (0.46) | OPRM1OGFRL1OPRL1TRPV1CDK4 | |
| SCHEMBL701237 | 0.89 | OPRM1 (0.46) | OPRM1OGFRL1LMNATP53OPRL1 | |
| SCHEMBL699422 | 0.89 | OPRM1 (0.45) | OPRM1OGFRL1OPRL1TRPV1CDK4 | |
| SCHEMBL700109 | 0.88 | OPRM1 (0.45) | OPRM1OGFRL1LMNAOPRL1TRPV1 | |
| SCHEMBL699379 | 0.88 | LMNA (0.48) | OPRM1OGFRL1LMNATP53OPRL1 | |
| SCHEMBL700318 | 0.88 | OPRM1 (0.45) | OPRM1OGFRL1OPRL1TRPV1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010531-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH ANALGESIC PROPERTIES | GRUENENTHAL GMBH (DE) | 2011-08-17 | — | — | EP | claimed |
| EP-2010531-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH ANALGESIC PROPERTIES | GRUENENTHAL GMBH (DE) | 2011-08-17 | — | — | EP | disclosed |
| EP-2010531-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007124903-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVE WITH ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2007-11-08 | — | — | WO | disclosed |