Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.52 |
| ▸ | MET | P08581 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371736 | 0.84 | MET (0.69) | KDRPDGFRAMET | |
| SCHEMBL14419321 | 0.83 | MET (0.55) | KDRPDGFRAMETKIT | |
| SCHEMBL409601 | 0.80 | MET (0.68) | KDRPDGFRAMETKITHDAC1 | |
| SCHEMBL377281 | 0.79 | MET (0.53) | KDRPDGFRAMETKIT | |
| SCHEMBL4610260 | 0.78 | MET (0.55) | KDRPDGFRAMETHDAC1 | |
| SCHEMBL371761 | 0.76 | MET (0.59) | KDRPDGFRAMET | |
| SCHEMBL372193 | 0.76 | MET (0.67) | KDRPDGFRAMET | |
| SCHEMBL371702 | 0.74 | MET (0.67) | KDRPDGFRAMET | |
| SCHEMBL5204832 | 0.72 | KDR (0.62) | KDRPDGFRAMETKIT | |
| SCHEMBL3906011 | 0.72 | KDR (0.54) | KDRPDGFRAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |